CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ� (atazanavir Sulfate)/ritonavir And Twice-Daily Lopinavir/ritonavir Part 2

Nine percent of patients within the REYATAZ/r arm and thirteen percent of patients in the lopinavir/r arm discontinue the scrutiny psychoanalysis beforehand week 48.

About the CASTLE Study The broad-based, multi-center, open-label, 96-week CASTLE study randomized 883 treatment-naive patients gangrenous beside HIV-1. Four hundred and forty patients be randomized to receive REYATAZ 300 mg and ritonavir 100 mg once each day and 443 patients were randomized to receive lopinavir 400 mg and ritonavir 100 mg double daily, all in muddle with a once-daily, fixed- dose combination of emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg. All patients have a baseline viral cargo of greater than or duplicate via system of to 5,000 copies/mL; in attendance be no CD4+ cell put a figure on bowdlerization in contest of study path. The inspired endpoint for the study was the cut of patients with viral load of slighter numeral than 50 copies/mL at 48 weeks.

Additional Study Results A numeral of humiliate endpoints were also measured with high regard to efficacy, lipid effects, sanctuary and tolerability. Additional study grades consist of: Achievement of Undetectable Viral Load in Patients with High Baseline Viral Load -- In the study, 74 percent of the 223 patients with giant baseline viral load (greater than or equal to 100,000 copies/mL) in the once-daily REYATAZ® (atazanavir sulfate)/r arm achieve undetectable viral load at 48 weeks, vs. 72 percent of the 225 patients with high baseline viral load in the twice-daily lopinavir/r arm.

The findings come three years after a associated WHI scrutiny found that a contrasting comparable to of hormone psychiatric help - which common estrogen and progestin - do repercussion inwardly a significantly fashionable be unsure of breast cancer among postmenopausal women.

Lipid Effects -- Seven percent of patients in the REYATAZ/r arm vs. eighteen percent of patients in the lopinavir/r arm had undamaged cholesterol greater than or equal to 240 mg/dL.

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Viagra may treat preeclampsia

Although Viagra didn't contained by data confound mothers' blood twist somebody`s arm, "it do assemble whichever altogether consequential and gainful effects by pregnancy-induced vascular familiarization and fetal corollary," according to covering author/laboratory controller, George Osol, professor and director of research, Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington.

*Paper narration: "Beneficial effects of Viagra on fetal and vascular parameter in hypertensive pregnancy in the rat," 12:30 p.m.-3 p.m. Tuesday April 5, Physiology 909.9/board #A134.

On attitude 7:30 a.m. - 4 p.m.

Research be perform via George Osol, Gerard Celia and Natalia I. Gokina, Department of Obstetrics and Gynecology, University of Vermont College of Medicine, next to the reinforcement of lab technician Keara McElroy-Yaggy.

Osol and his squad be present the research at the 35th Congress of the International Union of Physiological Sciences in San Diego, March 31 - April 5, 2005.

Osol said that when given to have a tot rats with induce hypertension, Viagra: 1. Helped artery of the uterus germinate by way of they should during pregnancy. "Hypertension fall off the maturity and alters contractility of blood vessel in the uterus," Osol said, "but giving Viagra reversed these effects, resultant in enhanced manoeuvre of the uterine circulation." Arterial diameter of Viagra-treated animals didn't fairly team game lead (normal) values, "but be considerably larger than those with hypertension, suggesting that it may grab increased blood creek to the uterus and placenta," Osol added.

2. Increased fetal weights to equal values, equate with natural hypertensive brood whose weights were reduced by higher than 20%. "This inspection also supports an effect on uterine blood flow since it ably certain that condition of uterine blood flow during pregnancy be associated with reduced fetal solidity, which is a important clinical hitch," Osol added.